Cellular Energy & Longevity. NAD+ is a coenzyme found in every living cell, essential for energy metabolism, DNA repair, and cellular signaling. NAD+...
NAD+ is a coenzyme found in every living cell, essential for energy metabolism, DNA repair, and cellular signaling. NAD+ levels naturally decline with age — approximately 50% between ages 40 and 60 — and this decline has been implicated in numerous age-related conditions. Injectable NAD+ has become one of the most popular compounds in longevity and biohacking communities.
NAD+ is a critical cofactor for sirtuins (SIRT1-7), enzymes involved in DNA repair, gene expression, and metabolic regulation. It plays a central role in mitochondrial function through the electron transport chain. NAD+ is also consumed by PARP enzymes during DNA damage repair and by CD38 in immune cell signaling. Supplementation aims to restore depleted cellular pools.
Important: The evidence base for NAD+ varies by application. Many findings are from preclinical (animal or in vitro) studies. Large-scale human clinical trials may not be completed. Always evaluate the quality of evidence before drawing conclusions.
IV NAD+ can cause flushing, nausea, chest tightness, and cramping during administration — generally dose-rate dependent and resolve when speed is reduced. SubQ NAD+ may cause injection site irritation and mild nausea. Long-term safety data for injectable NAD+ is limited.
NAD+ is not a controlled substance and is available as a research compound. It is also offered by wellness clinics as part of IV therapy protocols, though these uses are not FDA-approved for specific medical indications.
These verified suppliers carry NAD+ with third-party COAs and US-based shipping.